Abstract: The Nelder-Mead simplex method is a well-known algorithm enabling the minimization of functions that are not available in closed-form and that need not be differentiable or convex.

And Schafmeister isn’t the only chemist turning to modular methods of synthesis to explore vast regions of chemical space. It ...

We spoke to David Klenerman, co-developer of sequencing by synthesis, to find out how his work heralded the next generation ...