eLife reviews plant biology research including development, epigenetics, genomics, signalling, metabolism and plant-microbe interactions. Learn more about what we review and sign up for the latest ...

Brain organoids, also known as brain spheroids, are three-dimensional cultures of neural cells derived from pluripotent stem cells (PSCs) that mimic the brain’s organization, development, and activity ...

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

The Sox8 gene is capable of triggering female mice to develop male physical characteristics. In humans, mice and other mammals, genetic sex is determined by the combination of sex chromosomes that ...

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.

where ΔG (γ = 0) is the free energy difference at zero tension, γ the membrane tension and ΔA the in-plane cross sectional area change associated with channel opening (Haswell et al., 2011). Thus, ...

The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

Discussions around neurodiversity and neurodivergence in recent years have underscored the importance of listening to neurodivergent voices. With an emphasis on first-hand accounts, this collection ...

Brain abnormalities in the reading network have been repeatedly reported in individuals with developmental dyslexia (DD); however, it is still not totally understood where the structural and ...

This work advances on two Aso et al 2014 eLife papers to describe further resources that are valuable for the field. This paper identified and contributes additional MBON split-Gal4s, convincingly ...

Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.