Advancements in spatial proteomics enable detailed tissue mapping, linking protein localization to disease mechanisms and ...

Localizatome contains comprehensive information about the stress-induced protein localization changes within living cells. It provides open access to subcellular protein localization data through a ...

The functioning of neurons, cells that transmit information in the nervous system, heavily relies on the production of ...

An international team has assembled the first large-scale, publicly available map to show the impact of mutations on where proteins end up in the cell. The team developed a high-throughput imaging ...

Researchers developed a new machine learning method that, given a relevant amino acid sequence, can automatically predict the location of a protein in any human cell line down to the single-cell level ...

The team developed a high-throughput imaging platform to assess the influence of nearly 3,500 mutations on protein location. They found that roughly one in six disease-causing mutations led to ...

A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer's, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants ...