Cell surface interactions and receptor dynamics underpin every stage of immune function, from antigen recognition to effector responses. At the plasma membrane, receptors such as the T cell receptor ...

Recently these monocyte-derived alveolar macrophages, or Mo-AMs, were identified as key drivers of lung fibrosis disease progression. However, the mechanisms of their pro-fibrotic behavior and ...

Cell membrane receptors are important therapeutic targets in many diseases, including cancer. The efficacy of targeted protein degraders of intracellular proteins, such as proteolysis-targeting ...

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our ...

Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood cells that defend the body by killing microbes, removing dead cells and ...