Faithful duplication of the genome demands precise coordination between DNA replication and RNA transcription, two processes that share and compete for the same DNA template. When replication forks ...

A massively parallel reporter assay of 9,092 cortical-structure-associated variants reveals that Alu retrotransposons, Wnt ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural biologists at RIKEN. This could inform the development of new therapies. When ...

A vertical, purple double helix has a bumpy, light-blue shape attached at the bottom and a blue cross made of many strands at the top. One end of the cross is bright pink and has dots around it, and a ...

This article predates the current owners of Science Blog. It has not been reviewed under the current editorial process and is kept as part of the archive. Water molecules play an active, essential ...

Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A new study by researchers from the Center for Theoretical Biological ...

An essential cellular enzyme successfully transcribed synthetic DNA letters, bringing expanded genetic codes closer to biological use.

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Some things just go together like “rock and roll” and “fish and chips” or, in molecular biology, “transcription factors” and the “nearby genes they regulate.” The standard, simplified story goes like ...