A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

Amide bonds are ubiquitous in pharmaceuticals, agrochemicals and biomolecules, and their formation underpins the synthesis of peptides, proteins and small-molecule therapeutics. Traditional chemical ...

A team at UNC-Chapel Hill has developed a new process for synthesizing amides in a 100% atom-economical, sustainable fashion using Earth-abundant, environmentally friendly cobalt. UNC-Chapel Hill ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Figure 2. (Top) Adipic acid reacts with hexamethylenediamine to form an amide bond (red line), just like the reaction in Figure 1, but there's a big difference. The reaction product that I've called ...

Medicines come from chemical reactions, and better chemical reactions lead to better medicines. Yet, the most popular reaction used in drug discovery, called the amide coupling, makes an inherently ...

Single atom 'O' to 'S' substitution in cyclic peptides improves their membrane permeability and bioavailability. This study paves the way for developing next-generation peptide-based therapeutics. The ...